Pure Red Cell Aplasia - DR GHULAM YASEEN

Pure Red Cell Aplasia

Pure Red Cell Aplasia


Pure red cell aplasia is a very rare blood disorder in which the production of erythrocytes ceased due to the genetic mutation. It may occur in the patients that have a disease like tumors, systemic lupus erythematosus, thymomas, autoimmune diseases.

PRCA has following three types usually.

Congenital Pure Red Cell Aplasia: this is also called diamond-blackfan anemia. It is usually diagnosed in the first two years of life, but in severe conditions, it may be diagnosed in first 2,3 months of life. Half of the children with pure red cell aplasia show sign and symptoms of mental retardation or malformation. Only several hundred children reported cases of congenital aplasia worldwide.

Acquired red cell aplasia: This is a rare form of red cell aplasia in affecting adults. It is considered that acquired pure red cell aplasia is caused by any immune disorders, recurrent infections, certain medications and a tumor in the thymus gland.

Acute-self limiting pure red cell Aplasia: This is a most common type of red cell aplasia caused by a certain drug or viral attack.most of the time when virus or medicine eliminate from the body, the PRCA also disappear. If you already have hemolytic anemia, then PRCA can be fatal for you.

There is a difference in pure red cell aplasia and aplastic anemia. In aplastic anemia, all the RBCs, WBCs, and platelets become affected and in case of pure red cell aplasia only red blood cells line is affected, while the number of white blood cells and platelets remain in normal ranges.

Sign and symptoms

All patients of PRCA have anemia, its Sign and symptoms include:

  • Fatigue
  • Low count of red blood cells
  • Dizziness
  • Breathless
  • Pale skin

Patients with Acquired PRCA may have other sign and symptoms too, due to the underlying disease.

When to visit a doctor

If your child has paler complexion and showed sign and symptoms of anemia by birth, then immediately took him to the doctor. In acquired PRCA, patient experience this condition with other fatal health issues. It can be diagnosed with lab investigations, as the person visit the doctor.


Mostly it is assumed that PRCA is caused by autoimmune disorders and mistaken attack of the body’s own immune cells on the blood-forming stem cells.

  • Congenital
  • Certain drugs
  • Infections
  • Autoimmune disease
  • Idiopathic

Life expectancy with PRCA

  • Life expectancy with congenital pure red cell aplasia is limited.
  • Patients having PRCA due to the idiopathic cause have a life expectancy of 1-2decades.
  • The life span of the patients with Acquired PRCA depends upon the underlying disease.

Risk factors

Risk factors of PRCA include if you have :

  • Thymomas (tumors of the thymus gland)
  • Certain viruses like Parvovirus B-19
  • Inherited genetic disorders
  • Autoimmune diseases, like hepatitis, rheumatoid arthritis or having a clonal large population of lymphocytes that attack red blood cells precursors in the bone marrow.

Treatment at Saher Homeo Clinic

Here,we treat every individual at the genetic level. Every individual seeks treatment on the basis of symptoms and health condition. we have a number of completely cured cases. See their stories here





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